Answers:
depends where you are located. contained by the US you need to own an employer ID# from IRS.gov. you will have to directory quarterly 941 forms as well as 940 Unemployement Insurance. For states you will usually hold Unemployment Ins, disability insurance, workers compensation...

quicken has a payroll service that you can use through quickbooks, it is really easy to use.

you really could use a CPA to oblige you set this all up.

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